Share your sepsis story

Use #solvingsepsistogether @BARDA to join our mission and share your experience with sepsis.

Each year:
  • More than 1.7 million people in the U.S develop sepsis 1
  • Nearly 270,000 adult Americans die as a result of sepsis 1
  • More than $62 billion is spent on sepsis healthcare costs2

2 Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018. Crit Care Med 2020; 48:302-318

Solving Sepsis Strategy

The Solving Sepsis program is addressing the entire continuum of care of a sepsis patient – from early pre-hospital interactions with healthcare providers, through hospital care and discharge – seeking innovative interventions at each step to identify sepsis early, address clinical management in order to improve patient outcomes and decrease mortality. 

Sepsis Program Strategy

DRIVe Solving Sepsis aims to reduce the incidence, morbidity, mortality, and cost of sepsis by investing in key strategic areas

Sepsis Awards

Solving Sepsis is partnering with industry, academic and nonprofit groups to develop the following products to address sepsis.

Sepsis Program Strategy


Please carefully read the Solving Sepsis area of interest description in the EZ-BAA solicitation on located here. If you have any questions not answered in the solicitation or in these Frequently Asked Questions below, please email

A: Yes. The Solving Sepsis program is interested in host-based therapeutics that include demonstration of efficacy in sepsis-relevant models, with a clear regulatory plan for FDA approval.
A: Proposed approaches should include demonstration of effectiveness in sepsis relevant models (e.g. utilizing sepsis patient samples, sepsis patient data).
A: Solving Sepsis is interested in the host response to sepsis and therefore is only interested in host-based approaches when considering development of diagnostics, devices and therapeutics. BARDA has other existing programs for pathogen-targeted approaches.
A: References must be included in the technical description section of the application but can be provided as a text link to a compiled list of references. Additionally, a PMID can be provided instead of the full reference.
A: Solving Sepsis is interested in medical countermeasures that address sepsis of any etiology (i.e. bacterial, viral, other) versus approaches that are limited to sepsis induced by a subset of pathogens.
A: This may include establishment of partnerships with appropriate device fabricators/manufacturers, addressing the potential to scale, intellectual property and the means to address adoption in hospitals or other clinical settings.
A: The technology must demonstrate improved outcomes for sepsis patients. Please provide preliminary data to support the technology evaluated in sepsis patients or in a sepsis model.
A: Yes! Please reach out to so that we can coordinate with the appropriate division and discuss a cross-collaboration idea as well as the best mechanism to submit the idea.

Working Across The Government

The Solving Sepsis program is forming key partnerships across the U.S. Government to address sepsis by:

  • Examining the burden of sepsis in Medicare beneficiaries, conducting the largest known study of sepsis inpatient admissions to date, analyzing more than 9.5 million inpatient stays from 2012-2018.

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018. Crit Care Med 2020; 48:276-288.

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018. Crit Care Med 2020; 48:289-301.

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018. Crit Care Med 2020; 48:302-318

Critical Care Medicine 2020; 48(3)

Open Access, Supplemental Digital Content, and Visualizations are all available from the Society of Critical Care Medicine


  • Supporting BARDA partners to develop tools to raise awareness and educate on sepsis among healthcare professionals and for special populations.

Tim Buchman

Read the story of Solving Sepsis’ Dr. Tim Buchman and his encounter with sepsis:

Day four of the annual professional meeting began like so many others: I had one more talk to give, and then a dash to the airport for the flight home. At lunchtime, I noticed a slight headache. By the time the session began mid-afternoon, the headache was worse. I bummed a couple of over-the-counter pain pills...

Read More Here

Read about CDC’s Division of Health Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases Director, Dr. Denise Cardo’s statement on Why Each Person Matters:
Read More Here

Denise Headshot

From providing care to becoming a patient: A Level One Trauma center nurse’s experience with COVID-19 and Sepsis

As a nurse practitioner in a Level One Trauma center at UF Health, I know the signs of sepsis; I pay attention to the presentation with my trauma patients, but I never imagined that I could develop sepsis if I ever fell ill. Like every essential worker, I also was informed and alert about the risk of being exposed to COVID-19 from my patients and from my coworkers...

Read More Here
Denise Headshot


Initially, I thought I had a cold that wouldn’t be anything serious. However, I felt an obligation to be checked for COVID before seeing patients. After my nose was swabbed I said to myself, “Now I know what patients experience when I order a COVID test, and it is not fun!” To my surprise...

Read More Here

Download the Solving Sepsis Program Factsheet

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