solving sepsis together logo

Each year:
  • More than 1.7 million people in the U.S develop sepsis 1
  • Nearly 270,000 adult Americans die as a result of sepsis 1
  • More than $62 billion is spent on sepsis healthcare costs2

2 Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018. Crit Care Med 2020; 48:302-318

Solving Sepsis Strategy



Sepsis Program Strategy

DRIVe Solving Sepsis aims to reduce the incidence, morbidity, mortality and cost of sepsis by investing in key strategic areas

Investing across the PARADIGM


The Solving Sepsis program is addressing the entire continuum of care of a sepsis patient – from early pre-hospital interactions with healthcare providers, through hospital care and discharge – seeking innovative interventions at each step to identify sepsis early, address clinical management in order to improve patient outcomes and decrease mortality. Solving Sepsis is partnering with industry, academic and nonprofit groups to develop the following products to address sepsis.




FAQ



Please carefully read the Solving Sepsis area of interest description in the EZ-BAA solicitation on beta.sam.gov located here. If you have any questions not answered in the solicitation or in these Frequently Asked Questions below, please email SolvingSepsis@hhs.gov.

A: Yes. The Solving Sepsis program is interested in host-based therapeutics that include demonstration of efficacy in sepsis-relevant models, with a clear regulatory plan for FDA approval.
A: Proposed approaches should include demonstration of effectiveness in sepsis relevant models (e.g. utilizing sepsis patient samples, sepsis patient data).
A: Solving Sepsis is interested in the host response to sepsis and therefore is only interested in host-based approaches when considering development of diagnostics, devices and therapeutics. BARDA has other existing programs for pathogen-targeted approaches.
A: References must be included in the technical description section of the application but can be provided as a text link to a compiled list of references. Additionally, a PMID can be provided instead of the full reference.
A: Solving Sepsis is interested in medical countermeasures that address sepsis of any etiology (i.e. bacterial, viral, other) versus approaches that are limited to sepsis induced by a subset of pathogens.
A: This may include establishment of partnerships with appropriate device fabricators/manufacturers, addressing the potential to scale, intellectual property and the means to address adoption in hospitals or other clinical settings.
A: The technology must demonstrate improved outcomes for sepsis patients. Please provide preliminary data to support the technology evaluated in sepsis patients or in a sepsis model.
A: Yes! Please reach out to SolvingSepsis@hhs.gov so that we can coordinate with the appropriate division and discuss a cross-collaboration idea as well as the best mechanism to submit the idea.



Working Across The Government


The Solving Sepsis program is forming key partnerships across the U.S. Government to address sepsis by:

  • Examining the burden of sepsis in Medicare beneficiaries, conducting the largest known study of sepsis inpatient admissions to date, analyzing more than 9.5 million inpatient stays from 2012-2018.
References:

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 1. The Burdens of Sepsis, 2012-2018. Crit Care Med 2020; 48:276-288.

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 2. The Trajectories of Sepsis, 2012-2018. Crit Care Med 2020; 48:289-301.

Buchman TG, Simpson SQ, Sciarretta KL, et al: Sepsis Among Medicare Beneficiaries: 3. The Methods, Models, and Forecasts of Sepsis, 2012-2018. Crit Care Med 2020; 48:302-318

Critical Care Medicine 2020; 48(3)

Open Access, Supplemental Digital Content, and Visualizations are all available from the Society of Critical Care Medicine.

  • Supporting BARDA partners to develop tools to raise awareness and educate on sepsis among healthcare professionals and for special populations.


Sepsis Is Personal


The Solving Sepsis team has heard numerous personal stories about sepsis and sepsis loss and encountered many individuals whom are sepsis survivors. This has strengthened our commitment to working across government and with our external partners to combat sepsis.


Tim Buchman

Read the story of Solving Sepsis’ Dr. Tim Buchman and his encounter with sepsis:

Read More Here


Share your sepsis story


Use #solvingsepsistogether @BARDA to join our mission and share your experience with sepsis.

Read about CDC’s Division of Health Quality Promotion National Center for Emerging and Zoonotic Infectious Diseases Director, Dr. Denise Cardo’s statement on Why Each Person Matters:

Read More Here





Download the Solving Sepsis Program Factsheet

For more information, please contact us at solvingsepsis@hhs.gov

Submit your EZ BAA Abstract

DRIVe (Division of Research, Innovation, and Ventures) was established by the Biomedical Advanced Research and Development Authority (BARDA), part of the Assistant Secretary for Preparedness and Response (ASPR), within the United States Department of Health and Human Services (HHS).